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TULP3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75386 |
| Other Accession | NP_001153880.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49642 Da |
| Antigen Region | 374-400 aa |
| Gene ID | 7289 |
|---|---|
| Other Names | Tubby-related protein 3, Tubby-like protein 3, TULP3, TUBL3 |
| Target/Specificity | This TULP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-400 amino acids from the C-terminal region of human TULP3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TULP3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TULP3 (HGNC:12425) |
|---|---|
| Synonyms | TUBL3 |
| Function | Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT- A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes. |
| Cellular Location | Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm. Secreted. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha |
| Tissue Location | Expressed at high levels in testis, ovaries, thyroid, and spinal chord. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene.
References
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Ikeda, A., et al. J. Cell. Sci. 115 (PT 1), 9-14 (2002) :
Santagata, S., et al. Science 292(5524):2041-2050(2001)
Ikeda, S., et al. Invest. Ophthalmol. Vis. Sci. 40(11):2706-2712(1999)
Nishina, P.M., et al. Genomics 54(2):215-220(1998)
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