GKN1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9NS71 |
Other Accession | NP_062563.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 20331 Da |
Antigen Region | 124-150 aa |
Gene ID | 56287 |
---|---|
Other Names | Gastrokine-1, 18 kDa antrum mucosa protein, AMP-18, Protein CA11, GKN1, AMP18, CA11 |
Target/Specificity | This GKN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-150 amino acids from the C-terminal region of human GKN1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GKN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GKN1 |
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Synonyms | AMP18, CA11 |
Function | Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. |
Cellular Location | Secreted. Cytoplasmic granule. Golgi apparatus. Note=Shows abundant granular cytoplasmic staining, with perinuclear accentuation suggestive of the Golgi apparatus. |
Tissue Location | Expressed in stomach (at protein level). No expression is detected in cancer tissue or gastric cancer cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Broderick, P., et al. Cancer Res. 69(16):6633-6641(2009)
Nardone, G., et al. Cancer Biol. Ther. 7(12):1890-1895(2008)
Moss, S.F., et al. Clin. Cancer Res. 14(13):4161-4167(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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