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DRG2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P55039 |
| Other Accession | Q9QXB9, Q58D56, NP_001379.1 |
| Reactivity | Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40746 Da |
| Antigen Region | 154-180 aa |
| Gene ID | 1819 |
|---|---|
| Other Names | Developmentally-regulated GTP-binding protein 2, DRG-2, DRG2 |
| Target/Specificity | This DRG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-180 amino acids from the Central region of human DRG2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DRG2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DRG2 {ECO:0000303|PubMed:29915238, ECO:0000312|HGNC:HGNC:3030} |
|---|---|
| Function | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq].
References
Song, H., et al. J. Biochem. 135(3):331-335(2004)
Bi, W., et al. Genome Res. 12(5):713-728(2002)
Li, B., et al. Biochim. Biophys. Acta 1491 (1-3), 196-204 (2000) :
Vlangos, C.N., et al. Cytogenet. Cell Genet. 88 (3-4), 283-285 (2000) :
Liang, Y., et al. Genomics 61(3):243-258(1999)
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