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NAP1L1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P55209 |
| Other Accession | Q9Z2G8, P28656, A6H767 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45374 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 4673 |
|---|---|
| Other Names | Nucleosome assembly protein 1-like 1, NAP-1-related protein, hNRP, NAP1L1, NRP |
| Target/Specificity | This NAP1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NAP1L1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NAP1L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NAP1L1 |
|---|---|
| Synonyms | NRP |
| Function | Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:21211722, PubMed:26841755). Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616). Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). |
| Cellular Location | Nucleus. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
| Tissue Location | Ubiquitously expressed. |
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
NAP1L1 is a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation.
References
Rehtanz, M., et al., Mol. Cell. Biol. 24(5):2153-2168 (2004).
Simon, H.U., et al., Biochem. J. 297 (PT 2), 389-397 (1994) (): ().
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$ 365.00
$ 140.00
Cat# AP1920b
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