Mouse Ephb6 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O08644 |
Other Accession | P0C0K7, O15197, NP_001139823.1 |
Reactivity | Mouse |
Predicted | Human, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 110107 Da |
Antigen Region | 503-530 aa |
Gene ID | 13848 |
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Other Names | Ephrin type-B receptor 6, MEP, Tyrosine-protein kinase-defective receptor EPH-6, Ephb6, Cekl |
Target/Specificity | This Mouse Ephb6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 503-530 amino acids from the Central region of mouse Ephb6. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Ephb6 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Ephb6 |
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Synonyms | Cekl |
Function | Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted. |
Tissue Location | High level in thymus, and brain. Very low levels of expression in kidney, lung, liver, bone marrow, skeletal muscle, spleen from 2 week old and adult mice, heart, testes and embryonic stem cells |
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Background
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity).
References
Islam, S., et al. Dig. Dis. Sci. 55(9):2478-2488(2010)
Lieben, L., et al. Bone 47(2):301-308(2010)
Mordan-McCombs, S., et al. J. Steroid Biochem. Mol. Biol. 121 (1-2), 368-371 (2010) :
Zirzow, S., et al. Dev. Biol. 336(2):145-155(2009)
Chou, S.J., et al. Nat. Neurosci. 12(11):1381-1389(2009)
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