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Mouse Gnl3 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8CI11 |
| Other Accession | NP_705775.2 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60786 Da |
| Antigen Region | 442-471 aa |
| Gene ID | 30877 |
|---|---|
| Other Names | Guanine nucleotide-binding protein-like 3, Nucleolar GTP-binding protein 3, Nucleostemin, Gnl3, Ns |
| Target/Specificity | This Mouse Gnl3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-471 amino acids from the C-terminal region of mouse Gnl3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Gnl3 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Gnl3 |
|---|---|
| Synonyms | Ns |
| Function | May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. |
| Cellular Location | Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9} |
| Tissue Location | Expressed in the adult bone marrow population that is enriched in hematopoietic stem cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Gnl3 may be required to maintain the proliferative capacity of stem cells (By similarity).
References
Hirai, H., et al. Biochem. Biophys. Res. Commun. 391(1):299-304(2010)
Tamase, A., et al. Proc. Natl. Acad. Sci. U.S.A. 106(40):17163-17168(2009)
Nomura, J., et al. Stem Cells 27(5):1066-1076(2009)
Ohmura, M., et al. Stem Cells 26(12):3237-3246(2008)
Siddiqi, S., et al. Circ. Res. 103(1):89-97(2008)
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