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MTAP Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13126 |
| Other Accession | Q9CQ65, Q3MHF7, NP_002442.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31236 Da |
| Antigen Region | 8-37 aa |
| Gene ID | 4507 |
|---|---|
| Other Names | S-methyl-5'-thioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}, 24228 {ECO:0000255|HAMAP-Rule:MF_03155}, 5'-methylthioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}, MTA phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}, MTAP {ECO:0000255|HAMAP-Rule:MF_03155}, MTAPase {ECO:0000255|HAMAP-Rule:MF_03155}, MTAP {ECO:0000255|HAMAP-Rule:MF_03155}, MSAP |
| Target/Specificity | This MTAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human MTAP. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTAP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTAP {ECO:0000255|HAMAP-Rule:MF_03155} |
|---|---|
| Synonyms | MSAP |
| Function | Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|HAMAP- Rule:MF_03155} |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.
References
Newton-Bishop, J.A., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2043-2054(2010)
Yang, X.R., et al. Fam. Cancer (2010) In press :
Krasinskas, A.M., et al. Mod. Pathol. 23(4):531-538(2010)
Zhang, Q., et al. Zhonghua Liu Xing Bing Xue Za Zhi 31(1):83-86(2010)
Huang, H.Y., et al. Clin. Cancer Res. 15(22):6963-6972(2009)
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