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BCL6B Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - BCL6B Antibody (Center) AP20369c
    Anti-BCL6B Antibody (Center) at 1:2000 dilution + HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 52 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - BCL6B Antibody (Center) AP20369c
    BCL6B Antibody (Center) (Cat. #AP20369c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the BCL6B antibody detected the BCL6B protein (arrow).
  • SPECIFICATION
  • CITATIONS: 2
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8N143
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 276-302 aa
Additional Information
Other Names B-cell CLL/lymphoma 6 member B protein, Bcl6-associated zinc finger protein, Zinc finger protein 62, BCL6B, BAZF, ZNF62
Target/Specificity This BCL6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-302 amino acids from the Central region of human BCL6B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBCL6B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL6B
Synonyms BAZF, ZNF62
Function Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed with higher expression found in heart and placenta. EMBL; AB076580; BAC00962.1; -; mRNA EMBL; AB076581; BAC00963.1; -; Genomic_DNA EMBL; AC040977; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC059404; AAH59404.1; -; mRNA CCDS; CCDS42248.1; - PIR; JC7812; JC7812 RefSeq; NP_862827.1; NM_181844.3 SMR; Q8N143; - BioGRID; 129125; 21 IntAct; Q8N143; 2 STRING; 9606.ENSP00000293805; - iPTMnet; Q8N143; - PhosphoSitePlus; Q8N143; - BioMuta; BCL6B; - DMDM; 296434409; - jPOST; Q8N143; - MassIVE; Q8N143; - PaxDb; Q8N143; - PeptideAtlas; Q8N143; - PRIDE; Q8N143; - ProteomicsDB; 71552; - TopDownProteomics; Q8N143; - Antibodypedia; 23875; 73 antibodies DNASU; 255877; - Ensembl; ENST00000293805; ENSP00000293805; ENSG00000161940 GeneID; 255877; - KEGG; hsa:255877; - UCSC; uc010clt.2; human CTD; 255877; - DisGeNET; 255877; - EuPathDB; HostDB:ENSG00000161940.10; - GeneCards; BCL6B; - HGNC; HGNC:1002; BCL6B HPA; ENSG00000161940; Low tissue specificity MIM; 608992; gene neXtProt; NX_Q8N143; - OpenTargets; ENSG00000161940; - PharmGKB; PA25313; - eggNOG; KOG1721; Eukaryota GeneTree; ENSGT00940000159844; - HOGENOM; CLU_024196_2_0_1; - InParanoid; Q8N143; - KO; K22648; - OMA; VCGARFN; - OrthoDB; 1318335at2759; - PhylomeDB; Q8N143; - TreeFam; TF330912; - PathwayCommons; Q8N143; - BioGRID-ORCS; 255877; 5 hits in 895 CRISPR screens GenomeRNAi; 255877; - Pharos; Q8N143; Tbio PRO; PR:Q8N143; - Proteomes; UP000005640; Chromosome 17 RNAct; Q8N143; protein Bgee; ENSG00000161940; Expressed in heart left ventricle and 194 other tissues ExpressionAtlas; Q8N143; baseline and differential Genevisible; Q8N143; HS GO; GO:0005654; C:nucleoplasm; IBA:GO_Central GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central GO; GO:0045595; P:regulation of cell differentiation; IBA:GO_Central GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central GO; GO:0042092; P:type 2 immune response; IBA:GO_Central InterPro; IPR000210; BTB/POZ_dom InterPro; IPR011333; SKP1/BTB/POZ_sf InterPro; IPR036236; Znf_C2H2_sf InterPro; IPR013087; Znf_C2H2_type Pfam; PF00651; BTB; 1 Pfam; PF00096; zf-C2H2; 2 SMART; SM00225; BTB; 1 SMART; SM00355; ZnF_C2H2; 5 SUPFAM; SSF54695; SSF54695; 1 SUPFAM; SSF57667; SSF57667; 3 PROSITE; PS50097; BTB; 1 PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5 PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5 2: Evidence at transcript level; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger CHAIN 1..479 /note="B-cell CLL/lymphoma 6 member B protein" /id="PRO_0000047100" DOMAIN 38..105 /note="BTB" /evidence="ECO:0000255|PROSITE-ProRule:PRU00037" ZN_FING 328..350 /note="C2H2-type 1" /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" ZN_FING 356..378 /note="C2H2-type 2" /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" ZN_FING 384..406 /note="C2H2-type 3" /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" ZN_FING 412..434 /note="C2H2-type 4" /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" ZN_FING 440..463 /note="C2H2-type 5" /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" COMPBIAS 144..189 /note="Pro-rich" COMPBIAS 234..244 /note="Ser-rich" CONFLICT 244 /note="S -> SS (in Ref. 1; BAC00962/BAC00963 and 3; AAH59404)" /evidence="ECO:0000305" CONFLICT 306 /note="C -> S (in Ref. 3; AAH59404)" /evidence="ECO:0000305" SEQUENCE 479 AA; 51531 MW; AB04E3331A7DB8E6 CRC64; MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPLEAEPP TPPTAPPPGS PRRSEGHPDP PTESRSCSQG PPSPASPDPK ACNWKKYKYI VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS SSSSEEGPIP GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH TGEKPYHCSI CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR AHVLIHTGEK PYPCPTCGTR FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR HKSQLRLHLR QKHGAATNTK VHYHILGGP
Research Areas
Citations ( 0 )

Background

Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

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$ 162.50
$ 54.50
Cat# AP20369c
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