GTDC1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q4AE62 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 52597 Da |
Antigen Region | 278-304 aa |
Gene ID | 79712 |
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Other Names | Glycosyltransferase-like domain-containing protein 1, Mat-Xa, GTDC1 |
Target/Specificity | This GTDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-304 amino acids from the Central region of human GTDC1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GTDC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GTDC1 {ECO:0000303|PubMed:15068588, ECO:0000312|HGNC:HGNC:20887} |
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Function | Glycosyltransferase that specifically catalyzes mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)) (PubMed:37992713). Mannosylates the cyclopentene moiety of queuosine(34) in tRNA(Asp) to form mannosyl-queuosine(34) (PubMed:37992713). Mannosylation of queuosine(34) in tRNA(Asp) is required to slow-down elongation at cognate codons, GAC and GAU, thereby regulating protein translation (PubMed:37992713). |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Ubiquitous. Expressed at high levels in the lung, brain, spleen, testis, placenta. ovary, pancreas, spleen and peripheral blood leukocytes. Expressed at low level in the colon, small intestine, kidney, skeletal muscle and thymus. Expressed at high level in colon adenocarcinoma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of GTDC1 (glycosyltransferase like domain containing 1)remains unknown.
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