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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RCVRN Antibody (C-term)   

RCVRN Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RCVRN Antibody (C-term) AP20666c
    Western blot analysis of lysates from mouse eyeball and rat eyeball tissue lysate (from left to right), using RCVRN Antibody (C-term)(Cat. #AP20666c). AP20666c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P35243
Other Accession P34057
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23130 Da
Additional Information
Gene ID 5957
Other Names Recoverin, Cancer-associated retinopathy protein, Protein CAR, RCVRN, RCV1
Target/Specificity This RCVRN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 137-171 amino acids from the C-terminal region of human RCVRN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRCVRN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCVRN
Synonyms RCV1
Function Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity).
Cellular Location Photoreceptor inner segment {ECO:0000250|UniProtKB:P34057}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P34057}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon {ECO:0000250|UniProtKB:P34057}. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity) {ECO:0000250|UniProtKB:P21457, ECO:0000250|UniProtKB:P34057}
Tissue Location Retina and pineal gland.
Research Areas
Citations (0)

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Background

Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.

References

Murakami A.,et al.Biochem. Biophys. Res. Commun. 187:234-244(1992).
Wiechmann A.F.,et al.Exp. Eye Res. 56:463-470(1993).
Thirkill C.E.,et al.Invest. Ophthalmol. Vis. Sci. 33:2768-2772(1992).
Matsubara S.,et al.Br. J. Cancer 74:1419-1422(1996).
Polans A.S.,et al.J. Cell Biol. 112:981-989(1991).

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$ 325.00
$ 109.00
Cat# AP20666c
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