|Application ||WB, E|
|Calculated MW||77135 Da|
|Other Names||LIM domain-binding protein 3, Protein cypher, Z-band alternatively spliced PDZ-motif protein, LDB3 (HGNC:15710)|
|Target/Specificity||This LDB3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 101-134 amino acids from the N-terminal region of human LDB3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LDB3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.|
|Cellular Location||Cytoplasm, perinuclear region. Cell projection, pseudopodium. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines|
|Tissue Location||Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta|
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Provided below are standard protocols that you may find useful for product applications.
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
Faulkner G.,et al.J. Cell Biol. 146:465-475(1999).
Zeng G.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
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