|Application ||WB, E|
|Calculated MW||58844 Da|
|Other Names||Tyrosine-protein kinase FRK, Beta-cell Src-homology tyrosine kinase, BSK, FYN-related kinase, Intestine tyrosine kinase, Frk, Bsk, Iyk|
|Target/Specificity||This Mouse Frk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 476-509 amino acids from the C-terminal region of mouse Frk.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Frk Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.|
|Tissue Location||Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung|
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Provided below are standard protocols that you may find useful for product applications.
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
Thuveson M.,et al.Biochem. Biophys. Res. Commun. 209:582-589(1995).
Oberg-Welsh C.,et al.Gene 152:239-242(1995).
Carninci P.,et al.Science 309:1559-1563(2005).
Chandrasekharan S.,et al.Mol. Cell. Biol. 22:5235-5247(2002).
Welsh M.,et al.Biochem. J. 382:261-268(2004).
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