Mouse Frk Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q922K9 |
Other Accession | Q62662, NP_034367.2, NP_001153016.1 |
Reactivity | Mouse |
Predicted | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 58844 Da |
Antigen Region | 464-491 aa |
Gene ID | 14302 |
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Other Names | Tyrosine-protein kinase FRK, Beta-cell Src-homology tyrosine kinase, BSK, FYN-related kinase, Intestine tyrosine kinase, Frk, Bsk, Iyk |
Target/Specificity | This Mouse Frk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-491 amino acids from the C-terminal region of mouse Frk. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Frk Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Frk |
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Synonyms | Bsk, Iyk |
Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). |
Cellular Location | Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery. |
Tissue Location | Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung |
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Provided below are standard protocols that you may find useful for product applications.
Background
Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
References
Akerblom, B., et al. Mol. Cell. Endocrinol. 270 (1-2), 73-78 (2007) :
Nishimura, M., et al. DNA Res. 11(5):315-323(2004)
Sharov, A.A., et al. PLoS Biol. 1 (3), E74 (2003) :
Cowen, M.S., et al. Alcohol. Clin. Exp. Res. 27(8):1213-1219(2003)
Serfas, M.S., et al. Oncol. Res. 13 (6-10), 409-419 (2003) :
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