PPP6R1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9UPN7 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 96724 Da |
Gene ID | 22870 |
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Other Names | Serine/threonine-protein phosphatase 6 regulatory subunit 1, SAPS domain family member 1, PPP6R1, KIAA1115, PP6R1, SAPS1 |
Target/Specificity | This PPP6R1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 455-489 amino acids from the Central region of human PPP6R1. |
Dilution | WB~~1:1000-1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PPP6R1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PPP6R1 |
---|---|
Synonyms | KIAA1115, PP6R1, SAPS1 |
Function | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. |
Cellular Location | Cytoplasm |
Tissue Location | Ubiquitous with higher expression in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.
References
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Ohara O.,et al.Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
Olsen J.V.,et al.Cell 127:635-648(2006).
Stefansson B.,et al.J. Biol. Chem. 281:22624-22634(2006).
Stefansson B.,et al.Biochemistry 47:1442-1451(2008).
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