NACA2 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9H009 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 23223 Da |
Antigen Region | 36-69 aa |
Gene ID | 342538 |
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Other Names | Nascent polypeptide-associated complex subunit alpha-2, Alpha-NAC-like, Hom s 201, Nascent polypeptide-associated complex subunit alpha-like, NAC-alpha-like, NACA2, NACAL |
Target/Specificity | This NACA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 36-69 amino acids from human NACA2. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NACA2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NACA2 |
---|---|
Synonyms | NACAL |
Function | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). |
Cellular Location | Cytoplasm. Nucleus. |
Tissue Location | Expressed specifically in testis and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).
References
Mossabeb R.,et al.J. Invest. Dermatol. 119:820-829(2002).
Marques A.C.,et al.PLoS Biol. 3:E357-E357(2005).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
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