H1FNT Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q75WM6 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 28116 Da |
Antigen Region | 59-93 aa |
Gene ID | 341567 |
---|---|
Other Names | Testis-specific H1 histone, Haploid germ cell-specific nuclear protein 1, Histone H1t2, H1FNT, HANP1 |
Target/Specificity | This H1FNT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 59-93 amino acids from human H1FNT. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | H1FNT Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | H1-7 (HGNC:24893) |
---|---|
Function | Essential for normal spermatogenesis and male fertility (PubMed:16533358). Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single- stranded DNA, ATP and protamine-1. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q8CJI4}. Chromosome {ECO:0000250|UniProtKB:Q8CJI4}. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000250|UniProtKB:Q8CJI4} |
Tissue Location | Testis-specific.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone- protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity).
References
Huang C.Q.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
Tanaka H.,et al.Int. J. Androl. 29:353-359(2006).
Martianov I.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:2808-2813(2005).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.