CSNK2A3 Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q8NEV1 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 45220 Da |
Antigen Region | 296-330 aa |
Gene ID | 283106 |
---|---|
Other Names | Casein kinase II subunit alpha 3, CK II alpha 3, Casein kinase II alpha 1 polypeptide pseudogene, CSNK2A3, CSNK2A1P |
Target/Specificity | This CSNK2A3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 296-330 amino acids from human CSNK2A3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CSNK2A3 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CSNK2A3 |
---|---|
Synonyms | CSNK2A1P |
Function | Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression. |
Tissue Location | Detected in blood platelets and megakaryocyte cell lines. Poorly expressed in lung. Highly expressed in lung tumor tissues. |
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Background
Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down- regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.
References
Wirkner U.,et al.Biochim. Biophys. Acta 1131:220-222(1992).
Devilat I.,et al.FEBS Lett. 316:114-118(1993).
Singh L.S.,et al.Biochemistry 41:8935-8940(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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