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NAT8L Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P-Leica, E |
|---|---|
| Primary Accession | Q8N9F0 |
| Other Accession | Q3UGX3, D3ZVU9 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32837 Da |
| Gene ID | 339983 |
|---|---|
| Other Names | N-acetylaspartate synthetase, NAA synthetase, 2.3.1.17, Camello-like protein 3, N-acetyltransferase 8-like protein, NAT8L, CML3 |
| Target/Specificity | This NAT8L antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 59-93 amino acids from human NAT8L. |
| Dilution | WB~~1:1000 IHC-P-Leica~~1:250 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NAT8L Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NAT8L (HGNC:26742) |
|---|---|
| Synonyms | CML3 |
| Function | Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA (PubMed:19524112, PubMed:19807691, PubMed:20385109). Promotes dopamine uptake by regulating TNF-alpha expression (By similarity). Attenuates methamphetamine-induced inhibition of dopamine uptake (PubMed:20385109). |
| Cellular Location | Cytoplasm. Microsome membrane {ECO:0000250|UniProtKB:D3ZVU9}; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q3UGX3}; Single-pass membrane protein. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. |
| Tissue Location | Expressed in brain.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.
References
Hillier L.W.,et al.Nature 434:724-731(2005).
Brandenberger R.,et al.Nat. Biotechnol. 22:707-716(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Popsueva A.E.,et al.Dev. Biol. 234:483-496(2001).
Arun P.,et al.Neurochem. Int. 55:219-225(2009).
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