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KLB Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86Z14 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 119808 Da |
| Antigen Region | 1-29 aa |
| Gene ID | 152831 |
|---|---|
| Other Names | Beta-klotho, BKL, BetaKlotho, Klotho beta-like protein, KLB |
| Target/Specificity | This KLB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-29 amino acids from human KLB. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KLB Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KLB |
|---|---|
| Function | Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). |
| Cellular Location | Cell membrane; Single-pass type III membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
References
Hayashi A.,et al.Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
Wu X.,et al.J. Biol. Chem. 283:33304-33309(2008).
Micanovic R.,et al.J. Cell. Physiol. 219:227-234(2009).
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