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ACSS1 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NUB1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 74857 Da |
| Gene ID | 84532 |
|---|---|
| Other Names | Acetyl-coenzyme A synthetase 2-like, mitochondrial, 6.2.1.1, Acetate--CoA ligase 2, Acetyl-CoA synthetase 2, AceCS2, Acyl-CoA synthetase short-chain family member 1, ACSS1, ACAS2L, KIAA1846 |
| Target/Specificity | This ACSS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 94-125 amino acids from human ACSS1. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ACSS1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACSS1 |
|---|---|
| Synonyms | ACAS2L, KIAA1846 |
| Function | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity). |
| Cellular Location | Mitochondrion matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 8:85-95(2001).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
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