SLC14A2 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P-Leica, E |
---|---|
Primary Accession | Q15849 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 101209 Da |
Antigen Region | 42-76 aa |
Gene ID | 8170 |
---|---|
Other Names | Urea transporter 2, Solute carrier family 14 member 2, Urea transporter, kidney, SLC14A2, HUT2, UT2 |
Target/Specificity | This SLC14A2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 42-76 amino acids from the human region of human SLC14A2. |
Dilution | WB~~1:500 IHC-P-Leica~~1:500 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLC14A2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC14A2 |
---|---|
Synonyms | HUT2, UT2 |
Function | [Isoform 1]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. |
Cellular Location | [Isoform 1]: Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
Tissue Location | [Isoform 1]: Epressed in the inner medulla of the kidney (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.
References
Olives B.,et al.FEBS Lett. 386:156-160(1996).
Bagnasco S.M.,et al.Am. J. Physiol. 281:F400-F406(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mistry A.C.,et al.J. Biol. Chem. 282:30097-30106(2007).
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