NYREN18 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9Y5A7 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 70538 Da |
Antigen Region | 513-542 aa |
Gene ID | 51667 |
---|---|
Other Names | NEDD8 ultimate buster 1, Negative regulator of ubiquitin-like proteins 1, Renal carcinoma antigen NY-REN-18, NUB1, NYREN18 |
Target/Specificity | This NYREN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513-542 amino acids from the C-terminal region of human NYREN18. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NYREN18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NUB1 |
---|---|
Synonyms | NYREN18 |
Function | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. |
Cellular Location | Nucleus. Note=Predominantly nuclear |
Tissue Location | Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2 |
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Provided below are standard protocols that you may find useful for product applications.
Background
NYREN18 is a specific down-regulator of the NEDD8 conjugation system. It recruits NEDD8 and its conjugates to the proteasome for degradation. It also interacts with PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome.
References
Tanaka, T., et al., J. Biol. Chem. 278(35):32905-32913 (2003).
Akey, D.T., et al., Hum. Mol. Genet. 11(22):2723-2733 (2002).
Kito, K., et al., J. Biol. Chem. 276(23):20603-20609 (2001).
Scanlan, M.J., et al., Int. J. Cancer 83(4):456-464 (1999).
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