CPT2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P23786 |
Other Accession | Q60HG9 |
Reactivity | Human |
Predicted | Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 73777 Da |
Antigen Region | 6-38 aa |
Gene ID | 1376 |
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Other Names | Carnitine O-palmitoyltransferase 2, mitochondrial, Carnitine palmitoyltransferase II, CPT II, CPT2, CPT1 |
Target/Specificity | This CPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-38 amino acids from the N-terminal region of human CPT2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CPT2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CPT2 (HGNC:2330) |
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Synonyms | CPT1 |
Function | Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8- C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056). |
Cellular Location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side |
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Provided below are standard protocols that you may find useful for product applications.
Background
Carnitine palmitoyltransferase II precursor (CPT2) is a nuclear protein which is transported to the mitochondrial inner membrane. CPT2 together with carnitine palmitoyltransferase I oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders.
References
Deschauer, M., et al., Mol. Genet. Metab. 75(2):181-185 (2002).
Haap, M., et al., J. Clin. Endocrinol. Metab. 87(5):2139-2143 (2002).
Britton, C.H., et al., Proc. Natl. Acad. Sci. U.S.A. 92(6):1984-1988 (1995).
Verderio, E., et al., Hum. Mol. Genet. 4(1):19-29 (1995).
Montermini, L., et al., Biochim. Biophys. Acta 1219(1):237-240 (1994).
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