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CPT2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P23786 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 73777 Da |
| Antigen Region | 431-462 aa |
| Gene ID | 1376 |
|---|---|
| Other Names | Carnitine O-palmitoyltransferase 2, mitochondrial, Carnitine palmitoyltransferase II, CPT II, CPT2, CPT1 |
| Target/Specificity | This CPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 431-462 amino acids from the C-terminal region of human CPT2. |
| Dilution | WB~~1:1000 IF~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CPT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CPT2 (HGNC:2330) |
|---|---|
| Synonyms | CPT1 |
| Function | Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8- C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056). |
| Cellular Location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Carnitine palmitoyltransferase II precursor (CPT2) is a nuclear protein which is transported to the mitochondrial inner membrane. CPT2 together with carnitine palmitoyltransferase I oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders.
References
Deschauer, M., et al., Mol. Genet. Metab. 75(2):181-185 (2002).
Haap, M., et al., J. Clin. Endocrinol. Metab. 87(5):2139-2143 (2002).
Britton, C.H., et al., Proc. Natl. Acad. Sci. U.S.A. 92(6):1984-1988 (1995).
Verderio, E., et al., Hum. Mol. Genet. 4(1):19-29 (1995).
Montermini, L., et al., Biochim. Biophys. Acta 1219(1):237-240 (1994).
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