Arhgef9 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9QX73 |
Other Accession | Q3UTH8, O43307, Q58DL7 |
Reactivity | Rat |
Predicted | Bovine, Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 58157 Da |
Antigen Region | 274-303 aa |
Gene ID | 66013 |
---|---|
Other Names | Rho guanine nucleotide exchange factor 9, Collybistin, Rac/Cdc42 guanine nucleotide exchange factor 9, Arhgef9 |
Target/Specificity | This Arhgef9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-303 amino acids from the Central region of human Arhgef9. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Arhgef9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Arhgef9 |
---|---|
Function | Acts as a guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters. |
Cellular Location | Cytoplasm. Postsynaptic density {ECO:0000250|UniProtKB:Q3UTH8} |
Tissue Location | Detected in brain, throughout the gray matter. Detected at low levels in heart and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.
References
Xiang,S., J. Mol. Biol. 359 (1), 35-46 (2006)
Harvey,K., J. Neurosci. 24 (25), 5816-5826 (2004)
Grosskreutz,Y., Biol. Chem. 382 (10), 1455-1462 (2001)
Kins,S., Nat. Neurosci. 3 (1), 22-29 (2000)
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