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Phospho-Bik(T33) Antibody
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q13323 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 18016 Da |
| Gene ID | 638 |
|---|---|
| Other Names | Bcl-2-interacting killer, Apoptosis inducer NBK, BIP1, BP4, BIK, NBK |
| Target/Specificity | This Bik Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T33 of human Bik. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Phospho-Bik(T33) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BIK {ECO:0000303|PubMed:7478623, ECO:0000312|HGNC:HGNC:1051} |
|---|---|
| Function | Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. |
| Cellular Location | Endomembrane system; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:O70337}; Single-pass membrane protein. Note=Around the nuclear envelope, and in cytoplasmic membranes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.
References
Nikrad, M., et al., Mol. Cancer Ther. 4(3):443-449 (2005).
Dong, F., et al., Infect. Immun. 73(3):1861-1864 (2005).
Hur, J., et al., Proc. Natl. Acad. Sci. U.S.A. 101(8):2351-2356 (2004).
Gillissen, B., et al., EMBO J. 22(14):3580-3590 (2003).
Arena, V., et al., Genes Chromosomes Cancer 38(1):91-96 (2003).
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