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Phospho-IL3R(Y766) Antibody

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • DB - Phospho-IL3R(Y766) Antibody AP3133a
    Dot blot analysis of anti-hIL3R-pY766 Phospho-specific Pab (Cat. #AP3133a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, DB, E
Primary Accession P32927
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 97336 Da
Additional Information
Gene ID 1439
Other Names Cytokine receptor common subunit beta, CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, CD131, CSF2RB, IL3RB, IL5RB
Target/Specificity This IL3R Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y766 of human IL3R.
Dilution DB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-IL3R(Y766) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSF2RB
Synonyms IL3RB, IL5RB
Function Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK- STAT pathway (PubMed:9516124).
Cellular Location Membrane; Single-pass type I membrane protein.
Research Areas
Citations (0)
citation

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Background

IL3R (also known as CSF2RB) is a common beta chain of the high affinity receptor for IL-3, IL-5 and GM-CSF. Defective IL3R has been reported to be associated with protein alveolar proteinosis (PAP). PAP is an autosomal recessive fatal respiratory disease.

References

Murphy, J.M., et al., J. Biol. Chem. 279(25):26500-26508 (2004).
McClure, B.J., et al., Blood 101(4):1308-1315 (2003).
Scibek, J.J., et al., Anal. Biochem. 307(2):258-265 (2002).
Blake, T.J., et al., J. Leukoc. Biol. 72(6):1246-1255 (2002).
Evans, C.A., et al., Blood 100(9):3164-3174 (2002).

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$ 365.00
$ 140.00
Cat# AP3133a
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