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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > PAQR3 Antibody (C-term)
PAQR3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6TCH7 |
| Other Accession | Q6TCG8 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36217 Da |
| Antigen Region | 242-270 aa |
| Gene ID | 152559 |
|---|---|
| Other Names | Progestin and adipoQ receptor family member 3, Progestin and adipoQ receptor family member III, Raf kinase trapping to Golgi, RKTG, PAQR3 |
| Target/Specificity | This PAQR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-270 amino acids from the C-terminal region of human PAQR3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PAQR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAQR3 (HGNC:30130) |
|---|---|
| Function | Golgi-scaffold protein which modulates its interactors acitivies by anchoring them to the Golgi apparatus (PubMed:18547165, PubMed:26311497). Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus (PubMed:18547165). Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis (PubMed:26311497). Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation (By similarity). |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed in a range of tissues. |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
PAQR3 is function as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.
References
Jiang, Y., et al. Mol. Cell. Biol. 30(1):78-90(2010)
Garitaonandia, I., et al. J. Recept. Signal Transduct. Res. 29(1):67-73(2009)
Luo, X., et al. Biochem. J. 414(3):399-406(2008)
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$ 150.00
$ 385.00
Cat# AP4717b
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