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C1S Antibody (heavy chain, Cleaved-Arg437)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P09871 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 77 KDa |
| Antigen Region | 425-452 aa |
| Gene ID | 716 |
|---|---|
| Other Names | Complement C1s subcomponent, C1 esterase, Complement component 1 subcomponent s, Complement C1s subcomponent heavy chain, Complement C1s subcomponent light chain, C1S |
| Dilution | WB~~1:500 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | C1S {ECO:0000303|PubMed:3500856, ECO:0000312|HGNC:HGNC:1247} |
|---|---|
| Function | Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11445589, PubMed:16169853, PubMed:417728, PubMed:467643, PubMed:6271784, PubMed:6282646, PubMed:6319179, PubMed:70787, PubMed:9422791). C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens (PubMed:34155115). C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains (PubMed:11445589, PubMed:6271784). C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway (PubMed:16169853, PubMed:467643, PubMed:6282646, PubMed:6319179, PubMed:6906228, PubMed:70787, PubMed:9422791). |
| Cellular Location | Secreted. Cell surface. Note=Recruited to the surface of pathogens by the C1Q subcomplex. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
References
McKinnon C.M.,et al.Eur. J. Biochem. 169:547-553(1987).
Tosi M.,et al.Biochemistry 26:8516-8524(1987).
Kusumoto H.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:7307-7311(1988).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Endo Y.,et al.J. Immunol. 161:4924-4930(1998).
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