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Cadherin 23 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9H251 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59 KDa |
| Gene ID | 64072 |
|---|---|
| Other Names | Cadherin-23, Otocadherin, CDH23, KIAA1774, KIAA1812 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CDH23 {ECO:0000303|PubMed:11138009, ECO:0000312|HGNC:HGNC:13733} |
|---|---|
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Particularly strong expression in the retina (PubMed:11138009). Found also in the cochlea |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
References
Bolz H.,et al.Nat. Genet. 27:108-112(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Lagziel A.,et al.Dev. Biol. 280:295-306(2005).
Deloukas P.,et al.Nature 429:375-381(2004).
Nagase T.,et al.DNA Res. 8:85-95(2001).
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