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GRK6 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P43250 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 66 KDa |
| Antigen Region | 21 - 80 aa |
| Gene ID | 2870 |
|---|---|
| Other Names | G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6, GRK6, GPRK6 |
| Target/Specificity | KLH conjugated synthetic peptide derived from human GRK6 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | GRK6 |
|---|---|
| Synonyms | GPRK6 |
| Function | Specifically phosphorylates the activated forms of G protein- coupled receptors. Such receptor phosphorylation initiates beta- arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
| Cellular Location | Membrane; Lipid-anchor. |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
References
Benovic J.L.,et al.J. Biol. Chem. 268:19521-19527(1993).
Premont R.T.,et al.J. Biol. Chem. 274:29381-29389(1999).
Schmutz J.,et al.Nature 431:268-274(2004).
Haribabu B.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:9398-9402(1993).
Stoffel R.H.,et al.J. Biol. Chem. 269:27791-27794(1994).
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