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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > KLHL24 Antibody (Center)
KLHL24 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q6TFL4 |
| Other Accession | Q56A24, Q8BRG6 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 68361 Da |
| Antigen Region | 182-211 aa |
| Gene ID | 54800 |
|---|---|
| Other Names | Kelch-like protein 24, Kainate receptor-interacting protein for GluR6, KRIP6, Protein DRE1, KLHL24, DRE1 |
| Target/Specificity | This KLHL24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182-211 amino acids from the Central region of human KLHL24. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KLHL24 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KLHL24 |
|---|---|
| Synonyms | DRE1 |
| Function | Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function (PubMed:30715372). |
| Cellular Location | Perikaryon. Cell projection, axon {ECO:0000250|UniProtKB:Q56A24}. Cytoplasm {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27889062}. Cell junction, desmosome. Cell junction, adherens junction |
| Tissue Location | Expressed in the skin (PubMed:27798626, PubMed:27889062). Found in keratinocytes, dermal fibroblasts, and melanocytes (PubMed:27889062). Basal-layer keratinocytes have lower KLHL24 expression than suprabasal keratinocytes (PubMed:27798626) Expressed in the brain, spinal cord, liver, testis, heart and at higher levels in the skeletal muscle (PubMed:30715372) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLHL24 is specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.
References
Laezza, F., et al. Neuropharmacology 55(7):1131-1139(2008)
Laezza, F., et al. Mol. Cell. Neurosci. 34(4):539-550(2007)
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$ 385.00
$ 150.00
Cat# AP5238c
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