BRAP Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q7Z569 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Calculated MW | 67 KDa |
Gene ID | 8315 |
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Other Names | 3010002G07Rik;BRAP2;BRCA1 associated protein;EC 6.3.2.;Galectin 2 binding protein;IMP; Impedes mitogenic signal propagation;Renal carcinoma antigen NY REN 63; RING finger protein 52;RNF52;zgc:92894. |
Dilution | WB~~1:1000 |
Format | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | BRAP (HGNC:1099) |
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Synonyms | RNF52 |
Function | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. |
Cellular Location | Cytoplasm. |
Tissue Location | Expressed in breast epithelial cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
References
Li S.,et al.J. Biol. Chem. 273:6183-6189(1998).
Matheny S.A.,et al.Nature 427:256-260(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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