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SH2D2A Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NP31 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43 KDa |
| Antigen Region | 214-263 aa |
| Gene ID | 9047 |
|---|---|
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SH2D2A. The exact sequence is proprietary. |
| Dilution | WB~~1:1000 |
| Format | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SH2D2A |
|---|---|
| Synonyms | SCAP, TSAD, VRAP |
| Function | Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK- dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
References
Spurkland A.,et al.J. Biol. Chem. 273:4539-4546(1998).
Dai K.Z.,et al.Immunogenetics 51:179-185(2000).
Wu L.-W.,et al.J. Biol. Chem. 275:6059-6062(2000).
Lee J.-S.,et al.Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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