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CD45 (8C1) Mouse mAb
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | P06800 |
| Host | Mouse |
| Clonality | Monoclonal Antibody |
| Calculated MW | 144837 Da |
| Gene ID | 19264 |
|---|---|
| Other Names | GP180, L CA, CD45 antigen |
| Dilution | WB~~1:1000 IHC-P~~1:200 IF~~1:200 |
| Name | Ptprc {ECO:0000312|MGI:MGI:97810} |
|---|---|
| Synonyms | Ly-5 |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P08575}; Single-pass type I membrane protein. Membrane raft {ECO:0000250|UniProtKB:P08575}. Synapse {ECO:0000250|UniProtKB:P08575} Note=Colocalized with DPP4 in membrane rafts {ECO:0000250|UniProtKB:P08575} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Swiss-Prot Acc.P06800.Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN . Dephosphorylates LYN, and thereby modulates LYN activity.
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