Anti-PIK3R6 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q5UE93 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 84258 Da |
Gene ID | 146850 |
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Other Names | C17orf38; Phosphoinositide 3-kinase regulatory subunit 6; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; p84 PI3K adapter protein; p84 PIKAP; p87 PI3K adapter protein; p87PIKAP |
Target/Specificity | Recognizes endogenous levels of PIK3R6 protein. |
Dilution | WB~~1/500 - 1/1000 |
Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | PIK3R6 |
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Synonyms | C17orf38 |
Function | Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q3U6Q4}. Cell membrane {ECO:0000250|UniProtKB:Q3U6Q4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3U6Q4}. Note=Translocated to the plasma membrane in a Ras-dependent manner. {ECO:0000250|UniProtKB:Q3U6Q4} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Rabbit polyclonal antibody to PIK3R6
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