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Anti-GITRL Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UNG2 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20308 Da |
| Gene ID | 8995 |
|---|---|
| Other Names | AITRL; GITRL; TL6; Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GITRL. The exact sequence is proprietary. |
| Dilution | WB~~1/500 - 1/1000 |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TNFSF18 (HGNC:11932) |
|---|---|
| Synonyms | AITRL, GITRL, TL6 |
| Function | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T- cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Rabbit polyclonal antibody to GITRL
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$ 385.00
Cat# AP54053
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