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Anti-HPC2 Antibody

     
  • WB - Anti-HPC2 Antibody AP54095
    Western blot analysis of HPC2 expression in Panc1 (A), HEK293T (B) whole cell lysates.
    detail
  • IH - Anti-HPC2 Antibody AP54095
    Immunohistochemical analysis of HPC2 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q9BQ52
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 92219 Da
Additional Information
Gene ID 60528
Other Names HPC2; Zinc phosphodiesterase ELAC protein 2; ElaC homolog protein 2; Heredity prostate cancer protein 2; Ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z 2
Target/Specificity Recognizes endogenous levels of HPC2 protein.
Dilution WB~~1/500 - 1/1000
IH~~1/50 - 1/200
Format Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ELAC2
Synonyms HPC2
Function Zinc phosphodiesterase, which displays mitochondrial tRNA 3'- processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694).
Cellular Location Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Nucleus Note=Mainly mitochondrial
Tissue Location Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.
Research Areas
Citations (0)
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Background

Rabbit polyclonal antibody to HPC2

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$ 350.00
Cat# AP54095
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