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CRABP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P29762 |
| Other Accession | P62966, P62965, P40220, P62964, NP_004369.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Chicken, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 15566 Da |
| Antigen Region | 90-118 aa |
| Gene ID | 1381 |
|---|---|
| Other Names | Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP-I, CRABP1, RBP5 |
| Target/Specificity | This CRABP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-118 amino acids from the C-terminal region of human CRABP1. |
| Dilution | IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CRABP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRABP1 |
|---|---|
| Synonyms | RBP5 |
| Function | Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue.
References
Tang, X.H., et al. Exp. Cell Res. 314(1):38-51(2008)
Uhrig, M., et al. BMC Med 6, 38 (2008) :
Guidez, F., et al. Proc. Natl. Acad. Sci. U.S.A. 104(47):18694-18699(2007)
Tanaka, K., et al. Oncogene 26(44):6456-6468(2007)
Wu, Q., et al. Mol. Cancer 6, 45 (2007) :
Flagiello, D., et al. Cytogenet. Cell Genet. 76 (1-2), 17-18 (1997) :
Liu, W., et al. Biochem. Biophys. Res. Commun. 229(3):922-929(1996)
Eller, M.S., et al. Exp. Cell Res. 198(2):328-336(1992)
Astrom, A., et al. J. Biol. Chem. 266(26):17662-17666(1991)
Ong, D.E. Arch Dermatol 123 (12), 1693-1695A (1987) :
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