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VAMP1+VAMP2+VAMP3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | P23763 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13/11 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human VAMP-1+2+3 |
| Epitope Specificity | 21-118/118 |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein. |
| SIMILARITY | Belongs to the synaptobrevin family. Contains 1 v-SNARE coiled-coil homology domain. |
| SUBUNIT | Interacts with VAPA and VAPB. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]. |
| Gene ID | 6843 |
|---|---|
| Other Names | Vesicle-associated membrane protein 1, VAMP-1, Synaptobrevin-1, VAMP1, SYB1 |
| Target/Specificity | Nervous system, skeletal muscle and adipose tissue. |
| Dilution | WB=1:500-2000,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | VAMP1 |
|---|---|
| Synonyms | SYB1 |
| Function | Involved in the targeting and/or fusion of transport vesicles to their target membrane. |
| Cellular Location | [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Synapse, synaptosome [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein |
| Tissue Location | Nervous system, skeletal muscle and adipose tissue. |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP54261
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