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CCBL1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q16773 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 48 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CCBL1 |
| Epitope Specificity | 201-300/422 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. |
| SUBUNIT | Homodimer. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Gene ID | 883 |
|---|---|
| Other Names | Kynurenine--oxoglutarate transaminase 1, 2.6.1.7, Cysteine-S-conjugate beta-lyase, 4.4.1.13, Glutamine transaminase K, GTK, Glutamine--phenylpyruvate transaminase, 2.6.1.64, Kynurenine aminotransferase 1 {ECO:0000312|HGNC:HGNC:1564}, Kynurenine aminotransferase I, KATI, Kynurenine--oxoglutarate transaminase I, KYAT1 (HGNC:1564), CCBL1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | KYAT1 (HGNC:1564) |
|---|---|
| Synonyms | CCBL1 |
| Function | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047). |
| Cellular Location | Cytoplasm, cytosol. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP54327
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