PCDH1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| IHC-P, IHC-F, IF, ICC, E |
---|---|
Primary Accession | Q08174 |
Reactivity | Rat, Pig, Dog, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 110 KDa |
Physical State | Liquid |
Immunogen | KLH conjugated synthetic peptide derived from human PCDH1 |
Epitope Specificity | 51-150/1060 |
Isotype | IgG |
Purity | affinity purified by Protein A |
Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
SUBCELLULAR LOCATION | Cell junction. Cell membrane. Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. |
SIMILARITY | Contains 7 cadherin domains. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Background Descriptions | Protocadherins are a subfamily of cadherins, a large group of related glycoproteins that mediate calcium-dependent cell-to-cell adhesion via a homophilic mechanism. Involved in a variety of functions, protocadherins help to regulate neural development and synapse formation. PCDH1 is a 1,026 amino acid single-pass type I membrane protein that contains seven cadherin domains and is a member of the protocadherin family. Localized to cell-cell and cell-matrix boundaries and expressed at high levels in brain and neuro-glial cells, PCDH1 is thought to be involved in cell adhesion and cell-cell interactions and may play a role in neuronal development. PCDH1 contains a C-terminal cytoplasmic region, an extracellular region and a transmembrane region, and is expressed as two isoforms due to alternative splicing events. |
Gene ID | 5097 |
---|---|
Other Names | Protocadherin-1, Cadherin-like protein 1, Protocadherin-42, PC42, PCDH1 |
Target/Specificity | Highly expressed in the brain and neuro-glial cells. |
Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | PCDH1 |
---|---|
Function | May be involved in cell-cell interaction processes and in cell adhesion. |
Cellular Location | Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Found at cell- cell boundaries and probably at cell-matrix boundaries |
Tissue Location | Highly expressed in the brain and neuro-glial cells |

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