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Nocturnin Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q9UK39 |
| Reactivity | Rat, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 48196 Da |
| Gene ID | 25819 |
|---|---|
| Other Names | Nocturnin {ECO:0000312|HGNC:HGNC:14254}, 3.1.3.-, Carbon catabolite repression 4-like protein, NOCT (HGNC:14254), CCR4, CCRN4L, NOC |
| Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | NOCT (HGNC:14254) |
|---|---|
| Synonyms | CCR4, CCRN4L, NOC |
| Function | Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O35710}. Nucleus {ECO:0000250|UniProtKB:O35710}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O35710}. Mitochondrion |
| Tissue Location | Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP54504
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