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> home > Products > Primary Antibodies > Antibody Collections > mRNA processing > CCRN4L Antibody (C-term)
CCRN4L Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UK39 |
| Other Accession | Q9ET55, O35710 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48196 Da |
| Antigen Region | 309-336 aa |
| Gene ID | 25819 |
|---|---|
| Other Names | Nocturnin, Carbon catabolite repression 4-like protein, Circadian deadenylase NOC, CCRN4L, CCR4, NOC |
| Target/Specificity | This CCRN4L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-336 amino acids from the C-terminal region of human CCRN4L. |
| Dilution | FC~~1:10~50 WB~~1:1000 IHC-P~~1:50~100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCRN4L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOCT (HGNC:14254) |
|---|---|
| Synonyms | CCR4, CCRN4L, NOC |
| Function | Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O35710}. Nucleus {ECO:0000250|UniProtKB:O35710}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O35710}. Mitochondrion |
| Tissue Location | Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
CCRN4L is highly similar to Nocturnin, identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4).
References
Nakamura,E.S., Clin. Exp. Metastasis 23 (1), 9-18 (2006)
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$ 150.00
$ 385.00
Cat# AP6611B
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