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> home > Products > Primary Antibodies > Signal Transduction > Centaurin alpha 1 Polyclonal Antibody
Centaurin alpha 1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | O75689 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Centaurin alpha 1 |
| Epitope Specificity | 101-200/374 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cellular localizationCytoplasmic, Nuclear and Plasma membrane |
| SIMILARITY | Contains 1 Arf-GAP domain. Contains 2 PH domains. |
| SUBUNIT | Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1. |
| Post-translational modifications | Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP. |
| Gene ID | 11033 |
|---|---|
| Other Names | Arf-GAP with dual PH domain-containing protein 1, Centaurin-alpha-1, Cnt-a1, Putative MAPK-activating protein PM25, ADAP1, CENTA1 |
| Target/Specificity | Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | ADAP1 |
|---|---|
| Synonyms | CENTA1 |
| Function | GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). |
| Cellular Location | Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase |
| Tissue Location | Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes. |
Research Areas
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$ 192.50
⚠️ Limit: 5 vials per order for discount.
Cat# AP54539
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