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RAI3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q8NFJ5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40251 Da |
| Gene ID | 9052 |
|---|---|
| Other Names | Retinoic acid-induced protein 3, G-protein coupled receptor family C group 5 member A, Phorbol ester induced gene 1, PEIG-1, Retinoic acid-induced gene 1 protein, RAIG-1, GPRC5A, GPCR5A, RAI3, RAIG1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | GPRC5A |
|---|---|
| Synonyms | GPCR5A, RAI3, RAIG1 |
| Function | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in perinuclear vesicles, probably Golgi- associated vesicles. |
| Tissue Location | Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:18000218, PubMed:9857033). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal cord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart. |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP54555
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