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DNER Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q8NFT8 |
| Reactivity | Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 75 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DNER |
| Epitope Specificity | 185-300/737 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region. |
| SIMILARITY | Contains 10 EGF-like domains. Contains 1 follistatin-like domain. |
| SUBUNIT | Interacts with AP1G1. Interacts with NOTCH1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis. |
| Gene ID | 92737 |
|---|---|
| Other Names | Delta and Notch-like epidermal growth factor-related receptor, DNER, BET |
| Target/Specificity | Expressed in brain, spinal cord and adrenal gland. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | DNER |
|---|---|
| Synonyms | BET |
| Function | Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity). |
| Tissue Location | Expressed in brain, spinal cord and adrenal gland. |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP54729
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