Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
CTTB2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8WZ74 |
| Other Accession | Q2IBD4, NP_219499.1, Q2QLA2 |
| Reactivity | Human |
| Predicted | Horse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 181051 Da |
| Antigen Region | 72-100 aa |
| Gene ID | 83992 |
|---|---|
| Other Names | Cortactin-binding protein 2, CortBP2, CTTNBP2, C7orf8, CORTBP2, KIAA1758 |
| Target/Specificity | This CTTB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-100 amino acids from the N-terminal region of human CTTB2. |
| Dilution | IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTTB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTTNBP2 (HGNC:15679) |
|---|---|
| Function | Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons. |
| Cellular Location | Cytoplasm, cell cortex {ECO:0000250|UniProtKB:B9EJA2}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q2IBD4}. Note=Remains associated with dendritic spines even after glutamate stimulation {ECO:0000250|UniProtKB:Q2IBD4} |
| Tissue Location | Highest expression in brain. Also expressed in kidney, pancreas, lung, heart, liver, skeletal muscle and placenta |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
CTTB2 is a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq].
References
Zink, D., et al. J. Cell Biol. 166(6):815-825(2004)
Cheung, J., et al. Genomics 78 (1-2), 7-11 (2001)
Ohoka, Y., et al. Genes Cells 3(9):603-612(1998)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
