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CTTNBP2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q8WZ74 |
| Reactivity | Rat, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 181 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CTTNBP2 |
| Epitope Specificity | 1501-1663/1663 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasmic |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. CTTNBP2 regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance. |
| Gene ID | 83992 |
|---|---|
| Other Names | Cortactin-binding protein 2, CortBP2, CTTNBP2, C7orf8, CORTBP2, KIAA1758 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | CTTNBP2 (HGNC:15679) |
|---|---|
| Function | Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons. |
| Cellular Location | Cytoplasm, cell cortex {ECO:0000250|UniProtKB:B9EJA2}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q2IBD4}. Note=Remains associated with dendritic spines even after glutamate stimulation {ECO:0000250|UniProtKB:Q2IBD4} |
| Tissue Location | Highest expression in brain. Also expressed in kidney, pancreas, lung, heart, liver, skeletal muscle and placenta |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP55423
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