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KLF17 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q5JT82 |
| Other Accession | NP_775755.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42577 Da |
| Antigen Region | 243-271 aa |
| Gene ID | 128209 |
|---|---|
| Other Names | Krueppel-like factor 17, Zinc finger protein 393, KLF17, ZNF393 |
| Target/Specificity | This KLF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-271 amino acids of human KLF17. |
| Dilution | FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KLF17 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KLF17 |
|---|---|
| Synonyms | ZNF393 |
| Function | Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity). |
| Cellular Location | Nucleus. |
Provided below are standard protocols that you may find useful for product applications.
Background
KLF17 binds G/C-rich sites via its zinc fingers and activates transcription from CACCC-box elements. It may be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
References
Gumireddy, K., et al. Nat. Cell Biol. 11(11):1297-1304(2009) van Vliet, J., et al. Genomics 87(4):474-482(2006) Yan, W., et al. Mech. Dev. 118 (1-2), 233-239 (2002)
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